Protein name:
Endothelial PAS domain-containing protein 1 (EPAS-1) ;
Alternative:
HIF-related factor (HRF) ;HIF-1-alpha-like factor (HLF;mHLF) ;Hypoxia-inducible factor 2-alpha (HIF-2-alpha;HIF2-alpha) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerizes with ARNT. Interacts with CREBPB.
Function:
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MTADKEKKRS | SSELRKEKSR | DAARCRRSKE | TEVFYELAHE | LPLPHSVSSH |
100:
LDKASIMRLA | ISFLRTHKLL | SSVCSENESE | AEADQQMDNL | YLKALEGFIA |
150:
VVTQDGDMIF | LSENISKFMG | LTQVELTGHS | IFDFTHPCDH | EEIRENLTLK |
200:
NGSGFGKKSK | DVSTERDFFM | RMKCTVTNRG | RTVNLKSATW | KVLHCTGQVR |
250:
VYNNCPPHSS | LCGSKEPLLS | CLIIMCEPIQ | HPSHMDIPLD | SKTFLSRHSM |
300:
DMKFTYCDDR | ILELIGYHPE | ELLGRSAYEF | YHALDSENMT | KSHQNLCTKG |
350:
QVVSGQYRML | AKHGGYVWLE | TQGTVIYNPR | NLQPQCIMCV | NYVLSEIEKN |
400:
DVVFSMDQTE | SLFKPHLMAM | NSIFDSSDDV | AVTEKSNYLF | TKLKEEPEEL |
450:
AQLAPTPGDA | IISLDFGSQN | FDEPSAYGKA | ILPPGQPWVS | GLRSHSAQSE |
500:
SGSLPAFTVP | QADTPGNTTP | SASSSSSCST | PSSPEDYYSS | LENPLKIEVI |
550:
EKLFAMDTEP | RDPGSTQTDF | SELDLETLAP | YIPMDGEDFQ | LSPICPEEPL |
600:
MPESPQPTPQ | HCFSTMTSIF | QPLTPGATHG | PFFLDKYPQQ | LESRKTESEH |
650:
WPMSSIFFDA | GSKGSLSPCC | GQASTPLSSM | GGRSNTQWPP | DPPLHFGPTK |
700:
WPVGDQSAES | LGALPVGSSQ | LEPPSAPPHV | SMFKMRSAKD | FGARGPYMMS |
750:
PAMIALSNKL | KLKRQLEYEE | QAFQDTSGGD | PPGTSSSHLM | WKRMKSLMGG |
800:
TCPLMPDKTI | SANMAPDEFT | QKSMRGLGQP | LRHLPPPQPP | STRSSGENAK |
850:
TGFPPQCYAS | QFQDYGPPGA | QKVSGVASRL | LGPSFEPYLL | PELTRYDCEV |
874:
NVPVPGSSTL | LQGRDLLRAL | DQAT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse EPAS-1
ELISA Kit for Mouse EPAS-1
ELISA Kit for Mouse EPAS-1
CLIA Kit for Mouse EPAS-1
CLIA Kit for Mouse EPAS-1
CLIA Kit for Mouse EPAS-1
Polyclonal Antibody for Mouse EPAS-1
Polyclonal Antibody for Mouse EPAS-1
Polyclonal Antibody for Mouse EPAS-1
Monoclonal Antibody for Mouse EPAS-1
Monoclonal Antibody for Mouse EPAS-1
Monoclonal Antibody for Mouse EPAS-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
C57BL/6 .
tissue :
Hypothalamus .
tissue :
Skeletal muscle .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Brain capillary .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 846-864;MUTAGENESIS OF PRO-530 AND ASN-851
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CREBBP;PHOSPHORYLATION AT THR-844;MUTAGENESIS OF THR-844
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : HYDROXYLATION AT ASN-851